Acremonium strictum

W. Gams

(current name: Sarocladium strictum (W. Gams) Summerb)

What is Acremonium strictum?

Acremonium strictum (synonyms: Cephalosporium acremonium, Sarocladiom strictum) is a mold belonging to kingdom Fungi, division Ascomycota, class Sordariomicetes, order Hypocreales, family Sarocladiacea.

Genus Acremonium is a large and cosmopolitan group of filamentous Ascomycete fungi, including approximately 150 different species that are largely saprophytes, living on dead or decaying organic matter and contributing to the carbon cycle in the environment. Some Acremonium species occur as plant endophytes or plant pathogens, while some are animal pathogens, occasionally causing infection in immunocompromised humans (1).

Acremonium strictum is a common species, isolated mainly from soil and plants as well as indoor environments. This species is often found on moist, cellulose-based construction materials characterized by predominantly humid conditions (2). This species is a common fungal endophyte associated with a variety of grasses and the roots of maize plants and mangrove trees (3).

acrenomium strictum

Acremonium strictum morphology

Genus Acremonium includes many slow-growing, anamorphous, thread-like fungi with a simple structure (4). A. strictum is characterized by solitary, aculeate phialides or weakly branched conidiophores that arise from the vegetative filaments and bear a wet cluster or dry chains of mostly one-celled asexual spores (conidia). The filaments are sometimes bound together into “ropes” of several cells in diameter (5). Acremonium strictum growing at 30°C on glucose-peptone agar forms about 50 mm of mycelium in 7 days. The colonies are flattened, smooth, moist and fuzzy, and sometimes form thin cotton-like masses. The color of mycelium ranges from light pink to orange but may also be yellow, white, or green (6).

Acremonium strictum allergy

Molds of genus Acremonium may be toxic if ingested, and studies have shown that they may cause allergic reactions. Allergic individuals may develop symptoms of nausea, vomiting, and diarrhea. Studies have shown that Acremonium strictum may cause allergic rhinitis and asthma (7).

Even though these molds cause allergic reactions and infections of lungs, skin, and urinary tract (A. strictum, previously Cephalosporium acremonium), they also produce substances (cephalosporines) that are used for treating many infectious diseases, similarly to penicillin from the fungus Penicillium notatum. However, unrestricted use of these substances may lead to the appearance of mold in the mouth or on the vaginal mucous membrane (8).

Acremonium strictum infections

Acremonium strictum belongs to the group of fungi causing “hyalohyphomycosis”, a fungal infection caused by molds with basic tissue form of hyaline-based, pale hyphal elements that may be branched or unbranched and without pigments in their walls. This group includes widely distributed saprophytes such as Fusarium, Scedosporium, Scopulariopsis, Penicillium, Acremonium, and Paecilomyces (9). They contain agents that produce hyaline-based, septate mycelial elements with branched or intertwined hyphae. They cause various infections, mainly secondary infections that follow the primary ones (10,11).

In human patients, infection with these molds mostly occurs after the penetrating injuries, most commonly on extremities, but sometimes also in other body parts, such as the cornea (12). In the beginning, these infections are local even in immunocompromised individuals, but they are at risk of infection spread and creating systemic health problems (13). Cases of infection with species of genus Acremonium, including A. strictum, have been studied for several years. Unfortunately, the number of cases with infection caused by this type of mold has constantly been increasing, and there are also new, different types of infections.

Some studies have shown that in immunodeficient individuals with prior infections, this mold may cause serious ailments such as onychomycosis, otomycosis, and burn wound infection. Species of genus Acremonium also participate in creating and spreading infections such as pneumonia, arthritis, osteomyelitis, endocarditis, meningitis, and sepsis in immunodeficient patients (12). There are several recorded cases of hyalohyphomycosis caused by species of genus Acremonium. One of the interesting cases includes cutaneous hyalohyphomycosis caused by Acremonium strictum in an immunocompetent patient (14). In newborns, infections caused by A. strictum are sporadic, but such cases have been reported. In one instance, after a fatal outcome, the autopsy has shown A. strictum hyphae in a newborn’s brain, liver, and heart (15). It is believed that the increase in the frequency of these infections is partially caused by the implementation of modern medical techniques and the appearance of new diseases affecting the immune system in humans (12).

Acremonium strictum genome

After it was learned that A. strictum might produce enzymes that degrade lignocellulose (which constitutes the majority of plant material), it was later used in studies on biofuel production from degraded biomass. A particular strain of A. strictum (AAJ6) was used in that study, and it was proven that the genome of this mold species interacts with thermo-tolerant, industry-grade yeast to produce a higher amount of ethanol, while the time necessary for hydrolysis of cellulose decreases (16). Several different strains of A. strictum were used to elucidate its use in biomineralization processes, carbon cycle in nature, and production of CO2 (17).

Acremonium strictum treatment

A. strictum and many other species of genus Acremonium generally show resistance to most available antimycotics. However, it is still necessary to conduct studies to determine which combinations of antimycotics may influence the prevention or spread of infections caused by these molds. The most recent recommendations include the combination of amphotericin B and ketoconazole, as they have shown the best effects (18).

Just as in antibiotics used for bacterial infections, where many strains of bacteria now show significant resistance, it is necessary to search for new natural agents with antifungal activity continuously. It was determined in vitro that essential oils of certain plants (Cymbopogon schoenanthus, Hyptis spicigera, Lantana camara, and Ocimum americanum) inhibit the growth of mycelia in A. strictum as well as in other species of molds (Aspergillus niger, A. flavus, Cladosporium sp, Penicillium sp., Rhizopus sp., etc.) (19).

In everyday household conditions, it is necessary to perform preventive protection measures against molds, including A. strictum. It is necessary to minimize the time when open water containers are present, and rooms should be kept dry and well-aerated. It is advised to use a temperature and air humidity detector, especially in parts of an apartment or house where mold buildup is expected (bathroom, basement). If you suspect that Acremonium strictum is present, it is necessary to exterminate it immediately or call an expert.

And last but not least important: if you experience any permanent allergy or fungal infection symptoms, do not hesitate to contact your physician immediately.


  1. Schell, WA; Perfect, JR (1996). “Fatal, disseminated Acremonium strictum infection in a neutropenic host”. Journal of Clinical Microbiology. 34 (5):1333-6. doi:1128/JCM.34.5.1333-1336.
  2. Skrobot, F; Aglan, HA; Kitchens, S; Ludwick, A; Amburgey, T; Hamid, B; Diel, SV (2014). “Fungal populations in air and materials in a flood simulation study”. Wood and Fiber Science. 46 (3): 2–15.
  3. Leslie, J.F. (2008). Sorghum and Millets Diseases. John Wiley & Sons. pp. 188–189. ISBN978-0470384701.
  4. Summerbell, R.C.; Gueidan, C.; Schroers, H-J.; de Hoog, G.S.; Starink, M.; Arocha Rosete, Y.; Guarro, J.; James, J.A. (2011). Acremoniumphylogenetic overview and revision of Gliomastix, Sarocladium, and Trichothecium. Studies in Mycology. 68: 139–162. doi:3114/sim.2011.68.06.
  5. Guarro, J; Gams, W; Puhhol, I; Gene, J (1997). Acremoniumspecies: new emerging fungal opportunists—in vitro antifungal susceptibilities and review”. Clinical Infectious Diseases. 25 (5): 1222–1229. doi:1086/516098.
  6. Campbell, C.K; Johnson, E.M. (2013). Identification of Pathogenic Fungi. John Wiley & Sons. pp. 178–179. ISBN978-1118520048.
  7. Donald H BeezholdBrett J GreenFrancoise M BlachereDetlef SchmechelDavid N WeissmanDeborah VelickoffMary Beth HoganNevin W Wilson. Prevalence of allergic sensitization to indoor fungi in West Virginia. Allergy Asthma Proc. Jan-Feb 2008;29(1):29-34. doi: 10.2500/aap2008.29.3076.
  8. Abraham, E.P. Cephalosporins 1945–1986. Drugs. 34, 1–14 (1987).
  9. McGinnis MR, Ajello L. Conceptual basis for hyalohyphomycosis. In: Ajello L, Hay RJ, editors. Topley and Wilson’s Microbiology and Microbial Infections. London: Arnold Publisher; 1998. p. 499–502.
  10. Anadolu R, Hilmioglu S, Oskay T, Boyvat A, Peksari Y, Gurgey E. Indolent Acremonium strictum infection in animmunocompetent patient. Int J Dermatol. 2001; 40:451–3.
  11. Lopes JO, Kolling LC, Neumaier W. Kerion like lesion of the scalp due to Acremonium kiliense in a non-compromised boy. Rev Inst Med Trop Sao Paulo. 1995; 37:358–65.
  12. Fincher RME, Fisher JF, Lovell RD, Newman CL, Espinel-Ingroff A, Shadomy HJ. Infection due to the fungus Acremonium (Cephalosporium). Medicine. 1991; 70:398–409.
  13. Nucci M, Anaissie E. Emerging fungi. Infect Dis Clin NorthAm. 2006; 20:563–77.
  14. Ajanta Sharma •N. K. Hazarika •Purnima Barua •M R Shivaprakash •Arunaloke Chakrabarti. Acremonium strictum: Report of a Rare Emerging Agent of Cutaneous Hyalohyphomycosis with Review of Literatures. Mycopathologia (2013) 176:435–441. DOI 10.1007/s11046-013-9709-1.
  15. Mehmet Yalaz, Suleyha Hilmioglu, Dilek Metin, Mete Akisu, Deniz Nart, Hasan Cetin, Cengiz Ozturk, Ecmel Isik, Nilgun Kultursay. Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia. J Med Microbiol. 2003 Sep;52(Pt 9):835-837. doi: 10.1099/jmm.0.05140-0.
  16. Alberto Moura Mendeles Lopes, Allan Henrique Felix de Melo, Dielle Carvalho Nuria Adelentado, Goncalo A.G. Pereira Ferrer, Francisco Maugeri Filho, Rosane Goldbeck. Genome sequence of Acremonium strictum AAJ6 strain isolated from the Cerrado biome in Brazil and CAZymes expression in thermotolerant industrial yeast for ethanol production. Process Biochemistry, Volume 98, November 2020, Pages 139-150.
  17. Fuyumi Tojo, Ayumi Kitayama, Naoyuki Miyata, Kunihiro Okano, Jun Fukushima, Ryuichiro Suzuki and Yukinori Tani. Molecular Cloning and Heterologous Expression of Manganese (II)-Oxidizing Enzyme from Acremonium strictum Strain KR21-2. Catalysts 2020, 10, 686; doi:10.3390/catal10060686.
  18. F C Odds. (2021). Interactions among amphotericin B, 5-fluorocytosine, ketoconazole, and miconazole against pathogenic fungi in vitro. Antimicrobial Agents and Chemotherapy, 22, 5. DOI:
  19. Zida Pawinde Elisabeth, Sereme Paco, Leth Vibeke, Sankara Philippe, Somda Irenee, and Neya Adama, 2008. Importance of Seed-Borne Fungi of Sorghum and Pearl Millet in Burkina Faso and Their Control Using Plant Extracts. Pakistan Journal of Biological Sciences, 11: 321-331
  20. Featured image, Dr Jakson Kung, Mold Specialist.

Published: August 13, 2021 Updated: January 24, 2022

John Ward

Written by:

Account Executive
Mold Busters

Fact checked by:

Mold Busters

Charles Leduc
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